Changes in intracellular pH associated with glutamate excitotoxicity
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چکیده
منابع مشابه
Changes in intracellular pH associated with glutamate excitotoxicity.
Excitotoxic neuronal injury is known to be associated with increases in cytosolic calcium ion concentrations. However, it is not known if perturbations in other intracellular ions are also associated with glutamate (GLU)-induced neuronal death. Accordingly, intracellular hydrogen ion concentrations were measured in cultured hippocampal neurons with the fluorescent dye BCECF during and after tox...
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The Na⁺/H⁺ exchanger-1 (NHE-1) is a ubiquitously expressed pH-regulatory membrane protein that functions in the brain, heart, and other organs. It is increased by intracellular acidosis through the interaction of intracellular H⁺ with an allosteric modifier site in the transport domain. In the previous study, we reported that glutamate-induced NHE-1 phosphorylation mediated by activation of pro...
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The glutamate excitotoxicity hypothesis of ischemic cell damage holds that cell damage caused by transient cerebral ischemia is triggered by glutamate, released during ischemia from the intracellular compartment into the synaptic cleft: high extracellular glutamate levels activate ionotropic glutamate receptors, thus inducing an overflow of calcium ions into the neurones and a calcium-induced a...
متن کاملThe Interaction of Intracellular Mg 2+ and pH on C1- Fluxes Associated with Intracellular pH Regulation in Barnacle Muscle Fibers
The intraceilular dialysis technique was used to measure unidirectional C1fluxes and net acid extrusion by single muscle fibers from the giant barnacle. Decreasing pH~ below normal levels of 7.35 stimulated both CIeffiux and influx. These increases of CIfluxes were blocked by disulfonic acid stilbene derivatives such as SITS and DIDS. The SITS-sensitive C1effiux was sharply dependent upon pHi, ...
متن کاملThe interaction of intracellular Mg2+ and pH on Cl- fluxes associated with intracellular pH regulation in barnacle muscle fibers
The intracellular dialysis technique was used to measure unidirectional Cl- fluxes and net acid extrusion by single muscle fibers from the giant barnacle. Decreasing pHi below normal levels of 7.35 stimulated both Cl- efflux and influx. These increases of Cl- fluxes were blocked by disulfonic acid stilbene derivatives such as SITS and DIDS. The SITS-sensitive Cl- efflux was sharply dependent up...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1993
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.13-11-04690.1993